Careers

Join our Team

At Sio Gene Therapies, we are working together to develop gene therapies that will transform the lives of patients. Our team is committed to advancing our adult neurodegenerative and rare fatal pediatric programs through clinical development so that patients can access the therapies they need.

We are looking for people who are excited about cutting-edge science and want to build a world-class gene therapy company.

At Sio, we are location-agnostic and have capabilities to be fully virtual. We hire entrepreneurial, talented and passionate individuals regardless of location. Join our team if you want to push the boundaries of gene therapy to make a difference in the lives of patients.

Sio is Worldwide.

Full time position – Remote

Company Summary

Sio Gene Therapy is a biopharmaceutical company committed to developing treatments for CNS diseases. The company has rapidly built a diverse portfolio of gene therapy candidates with the potential to address debilitating CNS genetic diseases for which the unmet medical need is high, the biology for treatment is clear, and for which there are no approved therapies.  Additionally, the company is focused on more common debilitating CNS diseases, such as Parkinson’s Disease.

Developing new genetic treatments for these diseases is challenging work. It takes courage, talent, and dedication to look past the easy answers and uncover new solutions that can make a meaningful impact. At Sio we push each other to perform at our very best to make a difference in our patients’ lives.

Overall Summary

Sio Gene Therapies is seeking a highly motivated Director, Analytics, for Sio Gene Therapies’ AAV gene therapy programs. Reporting to the Vice President of Technical Operations, the Director, Analytical Development and Quality Control, will be responsible for the strategy and execution of development, qualification and validation activities related to AAV-based gene therapy programs, including oversight of activities at contract organizations, as well as providing support for relevant submissions to regulatory agencies.

Primary Responsibilities

These may include but are not limited to:

  • Development of phase-appropriate testing strategies for viral gene therapy vectors.
  • Identification and selection of contract testing organizations for performing development as well as product release testing.
  • Responsibility for the development and implementation of assays at contract laboratories.
  • Oversight of technical transfer between laboratories, qualification/validation of assays and QC activities for material release.
  • Coordination with internal and external parties, including Program Management, Process Development, Manufacturing, Supply chain, Quality Assurance, Regulatory Affairs and Clinical Operations.
  • Timely development of assays as well as testing of samples for material release.
  • Identification and communication of risks in assay performance and their mitigation.
  • Responsibility to develop, author, review, and/or approve Standard Operating Procedures, specifications, regulatory filing, or other controlled documents as needed.
  • Representation of the company as analytical expert.

Desired Skills and Experience

  • M.S or equivalent in Chemistry, Biological Sciences, Engineering or related discipline, with 10+ years of experience; Ph.D. with 6+ years of experience preferred.
  • Expertise in gene therapy projects required.
  • Familiar with assay development, qualification and validation activities essential.
  • Expertise in early development, preferably in late stage/commercial pharmaceutical projects.
  • Experience managing contract organizations.
  • Experience managing team members essential.
  • Familiar in efficiently interacting with Quality Assurance and Regulatory Affairs.
  • Occasional travel to contract organizations required.
  • Familiarity with regulatory requirement for testing of viral gene therapy products.
  • Excellent written and verbal communication skills, good interpersonal and management skills to collaborate with and direct the work of others on assigned projects (including both internal teams and external collaborators).
  • Results oriented, has a bias for action. Strong initiative, accountability and willingness to take ownership and drive projects to completion.
  • Accustomed “roll up their sleeves” and execute the tasks needed in a small company environment.
  • Ability to set priorities, work independently and deliver results in a timely manner. Display a sense of urgency.
  • Remote work location possible

This is an exciting time to join the field of gene therapy in general, and to become a part of Sio Gene Therapies’ fast-growing dedicated team. Sio Gene Therapies is a publicly traded company. We offer an exciting, meaningful and collaborative fast-paced environment with a foundation of sound and rigorous science. Competitive compensation and benefits package can be expected.

All interested applicants should send a cover letter and resume to:  HR@siogtx.com

Full time position – Remote

Company Summary

Sio Gene Therapies is a biopharmaceutical company committed to developing treatments for CNS diseases. The company has rapidly built a diverse portfolio of gene therapy candidates with the potential to address debilitating genetic CNS diseases for which the unmet medical need is high, the biology for treatment is clear, and for which there are no approved therapies.  Additionally, the company is focused on more common debilitating CNS diseases, such as Parkinson’s Disease.

Developing new genetic treatments for these diseases is challenging work. It takes courage, talent, and dedication to look past the easy answers and uncover new solutions that can make a meaningful impact. At Sio, we push each other to perform at our very best to make a difference in our patients’ lives.

Overall Summary

The Director, Global Project Management is responsible for directing the strategic and operational planning and delivery processes within Sio’s global development team(s). This leadership role serves as a partner working closely with the Global Project Leader and project team providing program management excellence to ensure robust cross-functional planning and alignment, facilitate decision-making and drive the implementation, monitoring, and reporting for one or more programs. The Director, GPM must be able to both guide the development of a unified strategic vision and drive the team to successfully execute on the agreed strategy. They will provide content expertise on the timing, costs and resources required to deliver to the defined program strategy, anticipate potential obstacles in the program and facilitate risk: benefit discussions driving the team to a clear direction and path forward.  In this role, the Director GPM will act as an operational leader to help the team achieve established objectives, facilitate governance interactions, and organize the needed tactics to make the project a success. The Director GPM will be responsible for one or more programs with significant complex cross-functional and/or cross-program initiatives within Sio’s pipeline.

Primary Responsibilities 

  • Strategic and tactical partner to the project team leader and line function representatives accountable to establish and deliver aligned cross functional plans across all relevant development functional groups into a cohesive development plan to deliver the agreed TPP and overall program.
  • Work closely with the Project Team Leader to facilitate the elaboration, approval and execution of the global program strategy and facilitate decision-making process through to Sio’s senior leadership team via the company’s governance process
  • Integrate, drive and deliver to ensure a cohesive project plan aligned to deliver an asset to a TPP.
  • Coordinate and drive development process planning activities of the project team including milestone setting, strategic integrated development plans, long range plans, budget inputs and go/no go criteria as appropriate.
  • Ensure transparency and understanding of the approved plan horizontally and vertically throughout the organization. Prepare and manage governance interactions to the Executive Team in partnership with the project leader and ensure timely input of program status/risks/issues throughout the organization.
  • Maintain the overall development plans for assigned program(s). Drive the cross-functional team to deliver to agreed goals.
  • Maintain all project management tools. Facilitate team meetings/agendas/minutes/action items including decision and action logs.
  • Coordinate team goal setting and tracking to ensure adherence to plan and agreed end of year milestones.
  • Manage set up of sub-teams and provide guidance on sub-team management. Participate in subteam meetings as appropriate to ensure alignment to the holistic project plan
  • In an alliance management role, liaise with partners, CMOs, etc. ensuring contractual obligations are met, and a healthy relationship is maintained. Participate in diligence in securing new relationships with partner as needed.
  • Partner with the VP, Project Management and other functional leaders to assess project management processes to ensure best practices are employed for the needs of the company

Requirements

  • Independent creative thinker and enabler requiring minimum oversight
  • A self-starter who is pro-active, motivates, and has tact, diplomacy, and is a team player
  • Excellent leadership skills with a history of delivering in a dynamic environment
  • Demonstrated ability to provide effective project management leadership in terms of setting project plans for the lifecycle of a program from discovery through launch
  • Proven track record of planning and managing complex programs in different phases of development including cross functional deliverables (Research, CMC and Commercial)
  • Solid understanding of the processes in drug development and appropriate regulatory guidelines
  • Strong influencing and interpersonal skills including negotiation, managing meetings and group dynamics, ability to balance concerns of line management with objectives of cross-functional team.
  • Ability to operate and motivate a team in a matrix environment and ability to work with / influence people at all levels in the organization without authority
  • Technical proficiency includes demonstrated proficiency in the use of project planning tools and systems (e.g. Microsoft Project or Smartsheet), resource forecasting, and the use of reporting tools.
  • Demonstrated understanding of program risk management and mitigation in order to simulate the likely obstacles to program progression.
  • Strong organizational skills with the ability to deal with competing priorities; high level of problem-solving capability and business acumen, ability to balance competing priorities and quickly and objectively drive the team towards a path which maximizes value
  • Excellent communication skills (written and verbal communication skills in English)
  • Highly skilled in negotiation, facilitation, and managing matrix team dynamics
  • At least 10 years of experience within one or more functional role(s) in pharmaceutical R&D drug development, biotechnology drug development, or related industry. Experience in gene therapy a plus. At least 5 years of cross-functional program management experience

WORKING CONDITIONS (ability to travel, lifting)

  • Ability to travel up to 25%

This is an exciting time to join the field of gene therapy in general, and to become a part of Sio Gene Therapies’ fast-growing dedicated team. Sio Gene Therapies is a publicly-traded company. We offer an exciting, meaningful and collaborative fast-paced environment with a foundation of sound and rigorous science. Competitive compensation and benefits package can be expected.

Interested applicants should send a cover letter and resume to:  HR@Siogtx.com

Full time position – Remote

Company Summary

Sio Gene Therapies is a biopharmaceutical company committed to developing treatments for CNS diseases. The company has rapidly built a diverse portfolio of gene therapy candidates with the potential to address debilitating genetic CNS diseases for which the unmet medical need is high, the biology for treatment is clear, and for which there are no approved therapies.  Additionally, the company is focused on more common debilitating CNS diseases, such as Parkinson’s Disease.

Developing new genetic treatments for these diseases is challenging work. It takes courage, talent, and dedication to look past the easy answers and uncover new solutions that can make a meaningful impact. At Sio, we push each other to perform at our very best to make a difference in our patients’ lives.

Overall Summary

Sio Gene Therapies is seeking a highly motivated Associate Director/Director, Process Development and Manufacturing, AAV vectors, for Sio Gene Therapies’ AAV gene therapy programs. Reporting to the Vice President of Technical Operations, the Associate Director/ Director, Process Development and Manufacturing, AAV vectors, will be responsible for identifying and implementing necessary process improvements, oversight of activities at contract development and manufacturing organizations (CDMOs), as well as authoring/review of relevant submissions to regulatory agencies.

Primary Responsibilities 

  • Identification of necessary process improvements, and management of development/ implementation of process improvements at external manufacturing sites.
  • Responsible for technical transfer to contract manufacturing organizations, as well as proper implementation of the process at the manufacturing sites.
  • Oversight of planning and proper execution of manufacturing runs at external CDMOs.
  • In coordination with Analytics, Supply Chain, Clinical Operations, Project Management and external CDMOs, forecasting of non-GMP and GMP manufacturing needs and scheduling of manufacturing runs in accordance with program timelines budgets.
  • Interaction as process development and manufacturing representative with internal and external parties, including Program Management, Analytics, Regulatory Affairs, Quality Assurance and Supply Chain.
  • Identification and communication of risks in the manufacturing process and their mitigation.
  • Responsibility to develop, author, review, and/or approve Standard Operating Procedures, specifications, reports, regulatory filings, or other controlled documents, as needed.
  • Representation of the company as AAV manufacturing process expert.

Requirements

  • M.S or equivalent in Chemistry, Biological Sciences, Engineering or related discipline, with 9+ years of experience; Ph.D. with 6+ years of experience preferred.
  • Expertise in development and manufacturing activities for early stage AAV products, preferably additional knowledge in late stage/commercial activities and plasmid manufacturing preferred.
  • Knowledge in interacting and coordinating efficiently with Analytics, Regulatory Affairs, Program Management and Quality Assurance.
  • Experience managing external contract organizations.
  • Up to 20% travel to contract organizations within the US and to Europe required.
  • Remote work location possible.
  • Excellent written and oral communication and collaboration skills across levels and functions.
  • Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment consisting of internal and external team members.
  • Results oriented, has a bias for action. Strong initiative, accountability and willingness to take ownership and drive projects to completion.
  • Accustomed “roll up their sleeves” and execute the tasks needed in a small company environment.
  • Ability to set priorities, work independently and deliver results in a timely manner. Display a sense of urgency.

This is an exciting time to join the field of gene therapy in general, and to become a part of Sio Gene Therapies’ fast-growing dedicated team. Sio Gene Therapies is a publicly-traded company. We offer an exciting, meaningful and collaborative fast-paced environment with a foundation of sound and rigorous science. Competitive compensation and benefits package can be expected.

Interested applicants should send a cover letter and resume to:  HR@Siogtx.com

For questions about working at Sio, please email hr@siogtx.com

Agencies & Recruiters

We maintain a list of approved professional recruiting agencies with which we have signed agreements. Candidates will be considered only when the agency has a signed agreement and Human Resources authorization to present candidates for a specified position(s). Candidates submitted outside of this process are considered unsolicited and will not be considered. Agencies interested in establishing a relationship with Sio may send company information to hr@siogtx.com. A member of the Human Resources team will contact you if we require the services your company offers.

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